Issue 27, 2022

Solid phase wax coating of N-acetylcysteine (NAC) to decrease its solubility profile as a ready to mix supplement

Abstract

N-Acetylcysteine (NAC) has health benefits attributed to its antioxidant properties and disulfide bond cleavage ability. Unfortunately, solutions of NAC are acidic with an undesirable taste and an unpleasant aftertaste. A method for slowing NAC release in water was developed using a solid phase wax coating. A coating of natural waxes, using food grade corn oil as the solvent and surfactants to facilitate the wax coating on the particles was used to decrease the solubility of NAC powder, crystals, and granules in water. A high NAC loading, between 55 and 91% for NAC granules and NAC crystals, was achieved as measured using LC-MS. The NAC wax-coated particles were fully characterized, and microscopy and SEM images revealed the shape, morphology, and size of the particles. Conductometry was used to study NAC release profile in water from wax-coated particles and the results indicate that solid phase wax coatings slowed the release of NAC into water.

Graphical abstract: Solid phase wax coating of N-acetylcysteine (NAC) to decrease its solubility profile as a ready to mix supplement

Supplementary files

Article information

Article type
Paper
Submitted
22 Dec 2021
Accepted
07 Jun 2022
First published
14 Jun 2022
This article is Open Access
Creative Commons BY license

RSC Adv., 2022,12, 17550-17558

Solid phase wax coating of N-acetylcysteine (NAC) to decrease its solubility profile as a ready to mix supplement

S. Madarshahian, M. Enayati, G. Vinyes Parés, G. Ufheil and A. Abbaspourrad, RSC Adv., 2022, 12, 17550 DOI: 10.1039/D1RA09279K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements