Issue 6, 2022, Issue in Progress

Acridine-based dyes as high-performance near-infrared Raman reporter molecules for cell imaging

Abstract

A surface-enhanced Raman scattering (SERS) nanoprobe has been proven to be a promising tool for near-infrared (NIR) biomedical imaging and diagnosis because of its high sensitivity and selectivity. However, the development of NIR SERS reporters has been a bottleneck impeding the preparation of ultrasensitive SERS probes. Herein, we report the design and synthesis of a series of SERS reporters in the NIR region based on 10-methylacridine (AD). The AD nanotags (gold nanostar–AD molecules–BSA, AuNS–AD–BSA) exhibit appreciable SERS signals and can be detected at as low as the sub-picomole level. The results of in vitro imaging experiments show that it can be used in live-cell delineation.

Graphical abstract: Acridine-based dyes as high-performance near-infrared Raman reporter molecules for cell imaging

Supplementary files

Article information

Article type
Paper
Submitted
04 Dec 2021
Accepted
14 Jan 2022
First published
25 Jan 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 3380-3385

Acridine-based dyes as high-performance near-infrared Raman reporter molecules for cell imaging

J. Du, J. Li, Y. Li, D. Wang, H. Cao, W. He and Y. Zhou, RSC Adv., 2022, 12, 3380 DOI: 10.1039/D1RA08827K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements