Copper halide mediated synthesis of mesoionic 6-halo-[1,2,3]triazolo[5,1-a]isoquinoliums: further transformation to polyheterocycles

Abstract

A highly efficient copper halide mediated oxidative cyclohalogenation approach toward mesoionic 6-halo-[1,2,3]triazo[5,1-a]isoquinoliums has been developed. The substrate scope is wide with broad functional group tolerance. In this transformation, concomitant C–N, C–O and C–X bond formation has been realized. Moreover, the products can be further transformed into other fused polyheterocyclic molecules.