Issue 23, 2022
From the journal:

Organic Chemistry Frontiers

Visible-light-initiated regio- and stereoselective C(sp2)–H phosphorylation of enamides under transition-metal-free conditions†

Ji-Yu Tao,‡a   Qing-Hong Zhang,‡a   Tong-Hao Zhu,‡ad   Xin-Wen Xu,‡a   Kun Ni,a   Qiao Zhao,a   Zheng-Bao Qin,a   Yu Zhang, ORCID logo b   Lili Zhao ORCID logo a  and  Kai Zhao ORCID logo *ac  

* Corresponding authors

a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China
E-mail: ias_kzhao@njtech.edu.cn

b College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

c Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China

d Institute of Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China

Abstract

A visible-light-induced stereo- and regioselective phosphorylation reaction of enamides with phosphine oxides has been disclosed, delivering synthetically and pharmaceutically appealing β-phosphorylated enamides with broad substrate scopes and excellent functional group tolerance under transition-metal-free conditions.

Graphical abstract: Visible-light-initiated regio- and stereoselective C(sp2)–H phosphorylation of enamides under transition-metal-free conditions

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Article information

DOI
https://doi.org/10.1039/D2QO01304E
Article type
Research Article
Submitted
14 Aug 2022
Accepted
06 Oct 2022
First published
07 Oct 2022

Org. Chem. Front., 2022,9, 6540-6546

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Visible-light-initiated regio- and stereoselective C(sp2)–H phosphorylation of enamides under transition-metal-free conditions

J. Tao, Q. Zhang, T. Zhu, X. Xu, K. Ni, Q. Zhao, Z. Qin, Y. Zhang, L. Zhao and K. Zhao, Org. Chem. Front., 2022, 9, 6540 DOI: 10.1039/D2QO01304E

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