An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to C![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
O and CN bonds
Xabier
del Corte, 
a
Edorta
Martínez de Marigorta,
a
Francisco
Palacios,
a
Javier
Vicario
*a
and
Aitor
Maestro
*a
a
Edorta
Martínez de Marigorta,
a
Francisco
Palacios,
a
Javier
Vicario
*a
and
Aitor
Maestro
*a
Abstract
Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first examples were reported 18 years ago by Akiyama and Terada. Although they were originally developed for enantioselective additions to imines, a wide reaction scope has been demonstrated using this type of catalyst. In this review, the known applications of CPA for enantioselective additions to CO and CN bonds are covered.
![Graphical abstract: An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to C [[double bond, length as m-dash]] O and C [[double bond, length as m-dash]] N bonds](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D2QO01209J&imageInfo.ImageIdentifier.Year=2022)
- This article is part of the themed collection: 2022 Organic Chemistry Frontiers Review-type Articles
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![[double bond, length as m-dash]](https://www.rsc.org/images/entities/h2_char_e001.gif)
O and C
