Issue 18, 2022

Asymmetric cross Rauhut–Currier reactions of vinyl ketones with carbonyl para-quinone methides via phosphine catalysis

Abstract

Novel cross Rauhut–Currier reactions involving chiral phosphine catalysis between vinyl ketones and terminal-carbonyl-substituted para-quinone methides have been presented. This reaction approach showed broad substrate scope compatibility and moderate-to-excellent enantioselectivity control. The multifunctional products could be easily transformed to important and useful skeletons. Moreover, natural-product and drug derivatives were well tolerated in this methodology, exhibiting the promising applications of this reaction approach.

Graphical abstract: Asymmetric cross Rauhut–Currier reactions of vinyl ketones with carbonyl para-quinone methides via phosphine catalysis

Supplementary files

Article information

Article type
Research Article
Submitted
28 May 2022
Accepted
21 Jul 2022
First published
29 Jul 2022

Org. Chem. Front., 2022,9, 4840-4845

Asymmetric cross Rauhut–Currier reactions of vinyl ketones with carbonyl para-quinone methides via phosphine catalysis

Y. Lu, N. He, X. Miao and D. Wang, Org. Chem. Front., 2022, 9, 4840 DOI: 10.1039/D2QO00866A

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