Copper-promoted cross-coupling of nitroarenes with 4-alkyl-1,4-dihydropyridines using a peroxide-driven radical reductive strategy

Abstract

A copper-promoted reductive cross-coupling of nitroarenes with 4-alkyl-1,4-dihydropyridines for producing N-alkylbenzenamines is described. Using 4-alkyl-1,4-dihydropyridines as alkyl radical sources and internal reducing agents enables the construction of C(sp³)–N bonds under oxidative conditions, which provide an elegant complementary platform to assemble N-alkylbenzenamines with good tolerance for sensitive functional groups.