Issue 17, 2022
From the journal:

Organic Chemistry Frontiers

Highly-selective synthesis of functionalized spirobenzofuranones and diketones†

Yin-Jun Chen,a   Hui-Bei Xu,a   Hao Liua  and  Lin Dong ORCID logo *a  

* Corresponding authors

a Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
E-mail: dongl@scu.edu.cn

Abstract

A convenient and atom-economical rhodium(III)-catalyzed highly-selective hydroacylation for the synthesis of spirobenzofuranones and diketones has been successfully developed. Ortho-hydroxyl-group-assisted aldehyde C–H cascade [4 + 1] annulation makes the formation of spiro compounds more efficient.

Graphical abstract: Highly-selective synthesis of functionalized spirobenzofuranones and diketones

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Article information

DOI
https://doi.org/10.1039/D2QO00677D
Article type
Research Article
Submitted
27 Apr 2022
Accepted
09 Jul 2022
First published
11 Jul 2022

Org. Chem. Front., 2022,9, 4633-4639

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Highly-selective synthesis of functionalized spirobenzofuranones and diketones

Y. Chen, H. Xu, H. Liu and L. Dong, Org. Chem. Front., 2022, 9, 4633 DOI: 10.1039/D2QO00677D

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