Issue 9, 2022

Mn(iii)-Catalyzed cascade cyclization reaction of o-acyl aromatic isocyanides with boronic acids

Abstract

A Mn(III)-catalyzed cascade cyclization of o-acyl aromatic isocyanides with boronic acids was carried out via a single-step route to generate a series of 3-hydroxyindolenines under mild conditions. A plausible mechanism involving a cascade transmetalation, nucleophilic addition and intramolecular cyclization sequence was proposed and confirmed. In addition, the reaction procedure featured simple synthesis, wide substrate scope, and excellent functional group compatibility.

Graphical abstract: Mn(iii)-Catalyzed cascade cyclization reaction of o-acyl aromatic isocyanides with boronic acids

Supplementary files

Article information

Article type
Research Article
Submitted
21 Feb 2022
Accepted
21 Mar 2022
First published
22 Mar 2022

Org. Chem. Front., 2022,9, 2486-2490

Mn(III)-Catalyzed cascade cyclization reaction of o-acyl aromatic isocyanides with boronic acids

J. Liu, L. Li, X. Bu, Y. Yuan, X. Wang, R. Sun, M. Zhou and H. Wang, Org. Chem. Front., 2022, 9, 2486 DOI: 10.1039/D2QO00271J

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