Issue 10, 2022

Electroreductive 4-pyridylation of unsaturated compounds using gaseous ammonia as a hydrogen source

Abstract

Electrochemical radical-cross-coupling with ammonia as a terminal reductant is reported in the reactions of α-Keto esters, β-keto esters, α,β-unsaturated esters, and α,β-unsaturated ketones with 4-CN pyridine. More than 50 corresponding pyridylation products were synthesized under constant current conditions using thiourea as an essential promoter to activate the intermediate derived from 4-CN pyridine.

Graphical abstract: Electroreductive 4-pyridylation of unsaturated compounds using gaseous ammonia as a hydrogen source

Supplementary files

Article information

Article type
Research Article
Submitted
25 Jan 2022
Accepted
21 Mar 2022
First published
22 Mar 2022

Org. Chem. Front., 2022,9, 2634-2639

Electroreductive 4-pyridylation of unsaturated compounds using gaseous ammonia as a hydrogen source

W. Ding, J. Sheng, J. Li and X. Cheng, Org. Chem. Front., 2022, 9, 2634 DOI: 10.1039/D2QO00132B

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