Direct access to α,α-chlorofluoro arylketones via mild electrophilic heterohalogenation of arylalkynes

Abstract

By employing a compatible system of selectfluor and NaCl, we herein report a new and practical approach for direct access to aryl α,α-chlorofluoro arylketones in aqueous trifluoroethanol via mild electrophilic heterohalogenation of arylalkynes, featuring metal-free conditions, readily available feedstocks, and good functional group tolerance. The present work offers a raw material basis for further preparation of fluorinated organic molecules.