Issue 7, 2022
From the journal:

Organic Chemistry Frontiers

Visible light mediated C–H trifluoromethylation of (hetero)arenes†

Fang Xiao,ab   Jin-Hong Lin, ORCID logo bc   Fei Hao, ORCID logo *bd   Xing Zheng,*a   Yu Guo ORCID logo *a  and  Ji-Chang Xiao ORCID logo *b  

* Corresponding authors

a Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang, P. R. China
E-mail: guoyuhy@126.com, zhengxing9166@sohu.com

b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China
E-mail: jchxiao@sioc.ac.cn

c Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai, China

d Shandong Provincial Key Laboratory of Molecular Engineering, Qilu University of Technology – Shandong Academy of Science, Ji'nan 250353, China
E-mail: haofei@qlu.edu.cn

Abstract

A protocol for visible light mediated C–H trifluoromethylation of unactivated (hetero)arenes under blue LED irradiation has been developed. The reaction enables the rapid construction of a range of CF3-containing (hetero)arenes in moderate to high yields from the readily accessible trifluoromethylsulfonyl-pyridinium salt (TFSP). This protocol is also suitable for nitrogen-containing aromatic heterocycles, which are potentially useful in medicinal chemistry.

Graphical abstract: Visible light mediated C–H trifluoromethylation of (hetero)arenes

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Article information

DOI
https://doi.org/10.1039/D2QO00067A
Article type
Research Article
Submitted
16 Jan 2022
Accepted
21 Feb 2022
First published
22 Feb 2022

Org. Chem. Front., 2022,9, 1982-1985

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Visible light mediated C–H trifluoromethylation of (hetero)arenes

F. Xiao, J. Lin, F. Hao, X. Zheng, Y. Guo and J. Xiao, Org. Chem. Front., 2022, 9, 1982 DOI: 10.1039/D2QO00067A

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