Total synthesis of (−)-amathaspiramide A via a one-pot aldol addition/transamidification reaction

Abstract

The total synthesis of (−)-amathaspiramide A was accomplished through the efficient construction of a chiral aza-spirobicyclic core using the aldol addition/transamidification cascade. The scope of the efficient construction methodology was investigated. Configuration adjustment via an asymmetric protonation process was applied as a vital step to obtain the right stereochemistry.