Issue 5, 2022

Rhodium-catalyzed dearomative rearrangement of 2-oxypyridines with cyclopropenes: access to N-alkylated 2-pyridones

Abstract

A rhodium-catalyzed dearomative rearrangement reaction of 2-oxypyridines has been developed by using cyclopropenes as carbene precursors. This protocol features broad substrate scope and mild reaction conditions, providing a reliable and practical approach for the highly efficient synthesis of 2-alkylated 2-pyridone derivatives from readily available O-substituted pyridine compounds.

Graphical abstract: Rhodium-catalyzed dearomative rearrangement of 2-oxypyridines with cyclopropenes: access to N-alkylated 2-pyridones

Supplementary files

Article information

Article type
Research Article
Submitted
29 Dec 2021
Accepted
18 Jan 2022
First published
19 Jan 2022

Org. Chem. Front., 2022,9, 1295-1299

Rhodium-catalyzed dearomative rearrangement of 2-oxypyridines with cyclopropenes: access to N-alkylated 2-pyridones

H. Cui, G. Xu, J. Zhu and J. Sun, Org. Chem. Front., 2022, 9, 1295 DOI: 10.1039/D1QO01937F

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