Regiodivergent hydroallylation of 1,3-diynes controlled by nickel and palladium catalysts

Abstract

A highly efficient hydroallylation reaction of 1,3-diynes with allylborons was developed, with the regioselectivity governed primarily by the appropriate choice of the metal. A series of unsymmetrical and symmetrical 1,3-diynes could undergo this transformation leading to the switch of two regioselective allyl-functionalized 1,3-enynes when palladium and nickel bearing easily available phosphorus ligands were respectively employed.