Issue 2, 2022
From the journal:

Organic Chemistry Frontiers

From imines to amides via NHC-mediated oxidation†

Shaofa Sun,‡a   Donghui Guo,‡b   Fangyi Lib  and  Jian Wang ORCID logo *ab  

* Corresponding authors

a College of Chemistry and Biological Sciences, Hubei University of Science and Technology, Hubei, China

b School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, P. R. China
E-mail: wangjian2012@tsinghua.edu.cn

Abstract

The unprecedented NHC-mediated oxidation of imines to amides is described. This protocol features broad substrate scope and allows rapid assembly of amides in good to high yields. Notably, this process includes not only the umpolung of imines, but also the discovery of NHC-bound 1,2-dioxetane intermediates.

Graphical abstract: From imines to amides via NHC-mediated oxidation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D1QO01661J
Article type
Research Article
Submitted
05 Nov 2021
Accepted
29 Nov 2021
First published
30 Nov 2021

Org. Chem. Front., 2022,9, 356-363

Permissions

Request permissions

From imines to amides via NHC-mediated oxidation

S. Sun, D. Guo, F. Li and J. Wang, Org. Chem. Front., 2022, 9, 356 DOI: 10.1039/D1QO01661J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements