Iridium(iii)-catalyzed two-fold C–H alkylation of BINOLs with allyl alcohols

Abstract

Ir(III)-Catalyzed C–H alkylation of BINOL units has been well examined by using allyl alcohols as coupling partners. Under the advantage of the pyridine guiding group, the efficient protocol allows the rapid synthesis of diverse BINOL carbonyl compounds with the retention of optical purity.