Issue 6, 2022
From the journal:

Organic Chemistry Frontiers

Cobalt-catalyzed cascade hydroalkenylation of 1,6-enynes with chalcones†

Chunxiang Pan,‡a   Gaowei Wang,‡a   Hengyuan Zhao,a   Jianxiao Ni,a   Ruifeng Fan,a   Yongyun Zhou,*a   Yuanbin Zhu,b   Shiyuan Wub  and  Baomin Fan ORCID logo *ab  

* Corresponding authors

a Key Laboratory of Advanced Synthetic Chemistry (Yunnan Minzu University), State Ethnic Affairs Commission, Kunming 650500, China
E-mail: zhouyy@ynni.edu.cn, FanBM@ynni.edu.cn

b Yunnan Tiefeng High Tech Mining Chemicals. Co. Ltd, Qingfeng Industrial Park, Lufeng, Yunnan Province, China

Abstract

An efficient stereoselective cobalt-catalyzed hydrovinylative cyclization of 1,6-enynes with chalcones to obtain functionalized pyrrolidines has been developed. The products were furnished in good yields with up to 93% ee. A plausible mechanism through which the transformation was initiated by cyclization of 1,6-enynes is proposed.

Graphical abstract: Cobalt-catalyzed cascade hydroalkenylation of 1,6-enynes with chalcones

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Article information

DOI
https://doi.org/10.1039/D1QO01450A
Article type
Research Article
Submitted
26 Sep 2021
Accepted
30 Jan 2022
First published
03 Feb 2022

Org. Chem. Front., 2022,9, 1616-1620

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Cobalt-catalyzed cascade hydroalkenylation of 1,6-enynes with chalcones

C. Pan, G. Wang, H. Zhao, J. Ni, R. Fan, Y. Zhou, Y. Zhu, S. Wu and B. Fan, Org. Chem. Front., 2022, 9, 1616 DOI: 10.1039/D1QO01450A

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