Aqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues

Abstract

Self-assemblies containing the nucleobase analogue 2,6-diacylaminopyridine (DAP) have been successfully prepared for the first time by aqueous seeded RAFT polymerization in high concentrations. For this purpose, a diblock copolymer containing poly(ethylene glycol) (PEG) and DAP polymethacrylate blocks was used as a macro-chain-transfer agent (PEG124-b-PDAP9-CTA) for the polymerization of 2-hydroxypropyl methacrylate (HPMA) in water. From the systematic variation of the degree of polymerization and solid concentration, a phase diagram has been generated that correlates both variables with the morphologies of this new system. Self-assemblies have been characterized by TEM and DLS, observing morphologies from low to high order (from spherical micelles to worms and to vesicles). Self-assembly morphologies are stable for almost a year, except in the case of worms that turn into spherical micelles after a few weeks. In addition, H-bonding supramolecular functionalization of the DAP repeating units during aqueous seeded RAFT polymerization has been examined by functionalization with a cross-linker with four thymine groups. Finally, the loading and the subsequent release of Nile Red have been proven in both supramolecular cross-linked and non-cross-linked self-assemblies.

Graphical abstract: Aqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues

Supplementary files

Article information

Article type
Paper
Submitted
30 Sep 2022
Accepted
21 Nov 2022
First published
22 Nov 2022

Polym. Chem., 2022, Advance Article

Aqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues

M. Abad, M. Nardi, L. Oriol, M. Piñol and E. Blasco, Polym. Chem., 2022, Advance Article , DOI: 10.1039/D2PY01250B

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