Issue 38, 2022

Synthesis of well-defined cyclic glycopolymers and the relationship between their physical properties and their interaction with lectins

Abstract

Cyclic polymers, which have a different topology from that of linear polymers, show potential as novel nanomaterials. In this communication, we report the synthesis of well-defined cyclic glycopolymers that have functional units for biomolecular recognition and evaluated their physical properties including molecular mobility. The suppressed molecular mobility of the cyclic glycopolymers was found to weaken their interactions with target proteins, demonstrating the influence of polymer topology on molecular recognition.

Graphical abstract: Synthesis of well-defined cyclic glycopolymers and the relationship between their physical properties and their interaction with lectins

Supplementary files

Article information

Article type
Communication
Submitted
19 Jul 2022
Accepted
09 Sep 2022
First published
10 Sep 2022

Polym. Chem., 2022,13, 5453-5457

Synthesis of well-defined cyclic glycopolymers and the relationship between their physical properties and their interaction with lectins

M. Nagao, Y. Hoshino and Y. Miura, Polym. Chem., 2022, 13, 5453 DOI: 10.1039/D2PY00941B

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