Issue 38, 2022
From the journal:

Polymer Chemistry

Rationally designed water-soluble AIE fluorescent polyester for the detection of oligomers based on the characteristics of HEWL amyloid fibrosis†

Zhimin Lu,a   Yixiu Wang,b   Junyong Zhang,a   Anrong Mao*b  and  Meidong Lang ORCID logo *a  

* Corresponding authors

a Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
E-mail: mdlang@ecust.edu.cn

b Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

Abstract

The detection of early amyloid products is of great significance for early diagnosis and prompt treatment of related diseases, but there are still challenges. Herein, we designed a water-soluble AIE polymer based on the characteristics of a model protein during fibrosis, and successfully used this stimulus-responsive polymer for oligomer detection.

Graphical abstract: Rationally designed water-soluble AIE fluorescent polyester for the detection of oligomers based on the characteristics of HEWL amyloid fibrosis

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Article information

DOI
https://doi.org/10.1039/D2PY00891B
Article type
Communication
Submitted
10 Jul 2022
Accepted
15 Sep 2022
First published
22 Sep 2022

Polym. Chem., 2022,13, 5463-5468

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Rationally designed water-soluble AIE fluorescent polyester for the detection of oligomers based on the characteristics of HEWL amyloid fibrosis

Z. Lu, Y. Wang, J. Zhang, A. Mao and M. Lang, Polym. Chem., 2022, 13, 5463 DOI: 10.1039/D2PY00891B

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