New strategies for the synthesis of 1- and 2-azetines and their applications as value-added building blocks
Michael R.
Gatazka, 
†a
Elvis C.
McFee,
†a
Cody H.
Ng,
†a
Emily R.
Wearing
†a
and
Corinna S.
Schindler
*a
†a
Elvis C.
McFee,
†a
Cody H.
Ng,
†a
Emily R.
Wearing
†a
and
Corinna S.
Schindler
*a
Abstract
Four-membered nitrogen-containing heterocycles are highly desirable functional groups with synthetic and biological applications. Unsaturated four-membered N-heterocycles, 1- and 2-azetines, are historically underexplored, but have recently been gaining interest due to the development of new synthetic methods to access these compounds, and to their potential as reactive intermediates. This review covers both the synthesis and applications of azetines, with a focus on synthetic methods to access azetines developed since 2018, and a comprehensive review of the reactivity and applications of azetines as starting materials or intermediates to access both other heterocycles and complex products.
- This article is part of the themed collection: Celebrating the 20th anniversary of Organic & Biomolecular Chemistry
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