Synthesis of acridines via copper-catalyzed amination/annulation cascades between arylboronic acids and anthranils

Abstract

Copper-catalyzed tandem cyclization reactions between arylboronic acids and anthranils have been established, providing new approaches for one-pot assembly of azacycle acridines. This one-pot protocol features simple operation, precious-metal-free conditions and good functional group compatibility, thus providing an efficient approach for the synthesis of a variety of acridines in moderate to good yields.

Graphical abstract: Synthesis of acridines via copper-catalyzed amination/annulation cascades between arylboronic acids and anthranils

Supplementary files

Article information

Article type
Paper
Submitted
18 Sep 2022
Accepted
22 Nov 2022
First published
23 Nov 2022

Org. Biomol. Chem., 2022, Advance Article

Synthesis of acridines via copper-catalyzed amination/annulation cascades between arylboronic acids and anthranils

Y. Li, L. Xu and Y. Wei, Org. Biomol. Chem., 2022, Advance Article , DOI: 10.1039/D2OB01705A

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