Issue 42, 2022

Facile construction of C,N-disulfonated 5-amino pyrazoles through an iodine-catalyzed cascade reaction

Abstract

A green and facile synthesis of previously unreported C,N-disulfonated 5-amino pyrazoles was established through an iodine-catalyzed cascade reaction of easily accessible sulfonyl hydrazides, β-ketonitriles, and sodium sulfinates. Diverse C,N-disulfonated 5-amino pyrazoles could be obtained in 38–88% yields. This methodology features green and mild conditions, broad substrate scope, and effortless work-up.

Graphical abstract: Facile construction of C,N-disulfonated 5-amino pyrazoles through an iodine-catalyzed cascade reaction

Supplementary files

Article information

Article type
Communication
Submitted
09 Sep 2022
Accepted
03 Oct 2022
First published
03 Oct 2022

Org. Biomol. Chem., 2022,20, 8187-8191

Facile construction of C,N-disulfonated 5-amino pyrazoles through an iodine-catalyzed cascade reaction

M. Geng, J. Kuang, W. Fang, M. Miao and Y. Ma, Org. Biomol. Chem., 2022, 20, 8187 DOI: 10.1039/D2OB01647H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements