Iodonium ylides: an emerging and alternative carbene precursor for C–H functionalizations

Abstract

The metal-catalyzed successive activation and functionalization of arene/heteroarene is one of the most fundamental transformations in organic synthesis and leads to privileged scaffolds in natural products, pharmaceuticals, agrochemicals, and fine chemicals. Particularly, transition-metal-catalyzed C–H functionalization of arenes with carbene precursors via metal carbene migratory insertion has been well studied. As a result, diverse carbene precursors have been evaluated, such as diazo compounds, sulfoxonium ylides, triazoles, etc. In addition, there have been significant developments with the use of iodonium ylides as carbene precursors in recent years, and these reactions proceed with high efficiencies and selectivities. This review provides a comprehensive overview of iodonium ylides in C–H functionalizations, including the scope, limitations, and their potential synthetic applications.

Graphical abstract: Iodonium ylides: an emerging and alternative carbene precursor for C–H functionalizations

Article information

Article type
Review Article
Submitted
09 Sep 2022
Accepted
10 Nov 2022
First published
23 Nov 2022

Org. Biomol. Chem., 2022, Advance Article

Iodonium ylides: an emerging and alternative carbene precursor for C–H functionalizations

S. Kumar, V. Borkar, Mohd. Mujahid, S. Nunewar and V. Kanchupalli, Org. Biomol. Chem., 2022, Advance Article , DOI: 10.1039/D2OB01644C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements