Issue 39, 2022

An electrochemical tandem Michael addition, azidation and intramolecular cyclization strategy for the synthesis of imidazole derivatives

Abstract

An electrochemical-oxidation-induced intramolecular annulation used for the synthesis of imidazole was developed under undivided electrolytic conditions. In an undivided cell, amines, alkynes and azides could smoothly participate in the transformation to furnish a variety of substituted imidazoles through the tandem Michael addition/azide/cycloamine reaction. The reaction could be easily handled and avoided the use of both transition metal catalysts and peroxide reagents, which is in line with the concept of green chemistry.

Graphical abstract: An electrochemical tandem Michael addition, azidation and intramolecular cyclization strategy for the synthesis of imidazole derivatives

Supplementary files

Article information

Article type
Paper
Submitted
20 Aug 2022
Accepted
15 Sep 2022
First published
16 Sep 2022

Org. Biomol. Chem., 2022,20, 7840-7844

An electrochemical tandem Michael addition, azidation and intramolecular cyclization strategy for the synthesis of imidazole derivatives

K. Zhou, S. Xia, Y. Liu and Z. Chen, Org. Biomol. Chem., 2022, 20, 7840 DOI: 10.1039/D2OB01501C

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