Deracemization of racemic alcohols combining photooxidation and biocatalytic reduction

Abstract

We described a cascade reaction for deracemization of racemic alcohols combining photooxidation and enzymatic reduction under mild conditions without the isolation of intermediate ketones. Using different ketoreductases, a variety of racemic alcohols can be successfully converted into (R)- or (S)-enantiomers in high yields (up to 95%) and stereoselectivity (up to 99%).