Imidazo[1,2-a]benzoazepines were prepared by Brønsted acid-mediated intramolecular alkyne-carbonyl metathesis (ACM). The starting materials, imidazole and benzimidazole derivatives, were prepared by N-alkylation, formylation and Sonogashira cross-coupling reaction. The final intramolecular ACM delivered the final products in good to excellent yields and with a wide tolerance towards functional groups.
![Graphical abstract: Synthesis of imidazo[1,2-a]benzoazepines by alkyne-carbonyl-metathesis](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D2OB01320G&imageInfo.ImageIdentifier.Year=2022)
M. Sobhani, R. M. Figueira de Abreu, A. Villinger, P. Ehlers and P. Langer, Org. Biomol. Chem., 2022, 20, 9207 DOI: 10.1039/D2OB01320G
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