Issue 34, 2022
From the journal:

Organic & Biomolecular Chemistry

A convenient synthesis of N-(hetero)arylamides by the oxidative coupling of methylheteroarenes with amines†

Anjali Jaiswal,a   Preetia  and  Krishna Nand Singh ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India
E-mail: knsingh@bhu.ac.in, knsinghbhu@yahoo.co.in

Abstract

An oxidative amidation of 2-methylpyridines/2-methylbenzimidazole with amines using copper acetate and elemental sulfur in DMSO to afford various N-(hetero)arylamides has been accomplished. Mechanistic studies reveal the intermediacy of N-(pyridin-2-ylmethyl)aniline and confirm the role of DMSO as the oxygen source.

Graphical abstract: A convenient synthesis of N-(hetero)arylamides by the oxidative coupling of methylheteroarenes with amines

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Article information

DOI
https://doi.org/10.1039/D2OB01106A
Article type
Paper
Submitted
16 Jun 2022
Accepted
10 Aug 2022
First published
10 Aug 2022

Org. Biomol. Chem., 2022,20, 6915-6922

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A convenient synthesis of N-(hetero)arylamides by the oxidative coupling of methylheteroarenes with amines

A. Jaiswal, Preeti and K. N. Singh, Org. Biomol. Chem., 2022, 20, 6915 DOI: 10.1039/D2OB01106A

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