Issue 29, 2022

The regioselective synthesis of 2,5- and 4,5-disubstituted thiazoles via the cyclization of 2-oxo-2-(amino)ethanedithioates with isocyanides

Abstract

The regioselective synthesis of 2-(methylthio)-N-aryl/alkylthiazole-5-carboxamides and ethyl-5-(aryl/alkyl carbamoyl)thiazole-4-carboxylates was carried out via the base-induced cyclization of methyl-2-oxo-2-(amino)ethanedithioates with TosMIC and ethyl isocyanoacetate, respectively, with high yields. The regioisomeric products were confirmed based on X-ray diffraction studies. An advantage of the present method is the wide-ranging isocyanide reactivity compared to earlier protocols, while the catalyst-free nature and rapid reaction times are noteworthy features.

Graphical abstract: The regioselective synthesis of 2,5- and 4,5-disubstituted thiazoles via the cyclization of 2-oxo-2-(amino)ethanedithioates with isocyanides

Supplementary files

Article information

Article type
Paper
Submitted
03 May 2022
Accepted
22 Jun 2022
First published
22 Jun 2022

Org. Biomol. Chem., 2022,20, 5771-5778

The regioselective synthesis of 2,5- and 4,5-disubstituted thiazoles via the cyclization of 2-oxo-2-(amino)ethanedithioates with isocyanides

K. Ravi Singh, C. Santhosh, T. R. Swaroop and M. P. Sadashiva, Org. Biomol. Chem., 2022, 20, 5771 DOI: 10.1039/D2OB00837H

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