Issue 22, 2022

Copper-catalyzed C-3 benzylation of quinoxalin-2(1H)-ones with benzylsulfonyl hydrazides

Abstract

An unprecedented use of benzylsulfonyl hydrazides as benzylating agents has been demonstrated in the direct C-3 benzylation of quinoxalin-2(1H)-ones. A range of benzylsulfonyl hydrazides participated in the C-3 benzylation of quinoxalin-2(1H)-ones with CuCN as the catalyst and DTBP as the oxidant, delivering structurally diverse 3-benzylquinoxalin-2(1H)-ones in moderate to good yields.

Graphical abstract: Copper-catalyzed C-3 benzylation of quinoxalin-2(1H)-ones with benzylsulfonyl hydrazides

Supplementary files

Article information

Article type
Communication
Submitted
20 Apr 2022
Accepted
17 May 2022
First published
18 May 2022

Org. Biomol. Chem., 2022,20, 4518-4521

Copper-catalyzed C-3 benzylation of quinoxalin-2(1H)-ones with benzylsulfonyl hydrazides

D. Xie, R. Tian, X. Zhang and S. Tian, Org. Biomol. Chem., 2022, 20, 4518 DOI: 10.1039/D2OB00744D

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