Issue 19, 2022

Pd-Catalyzed carbonylative lactonization of 2-halidearomatic aldehydes with H2O as a nucleophile

Abstract

A palladium-catalyzed carbonylative cyclization reaction of 2-halidebenzaldehydes with H2O is described, which provides a strategy for the synthesis of diversely substituted 3,3′-oxyphthalides. Notably, the obtained 3,3′-oxyphthalide could be easily transformed into 3-aryl and alkyl phthalides with excellent efficiency using organozinc reagents under mild reaction conditions.

Graphical abstract: Pd-Catalyzed carbonylative lactonization of 2-halidearomatic aldehydes with H2O as a nucleophile

Supplementary files

Article information

Article type
Communication
Submitted
02 Apr 2022
Accepted
25 Apr 2022
First published
29 Apr 2022

Org. Biomol. Chem., 2022,20, 3917-3921

Pd-Catalyzed carbonylative lactonization of 2-halidearomatic aldehydes with H2O as a nucleophile

M. Si, J. Yan, Y. Ding and H. Huang, Org. Biomol. Chem., 2022, 20, 3917 DOI: 10.1039/D2OB00623E

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