The clinically used DNA-alkylating drug streptozotocin (STZ) was investigated using a simple work-up as an O-methylating agent to transform various carboxylic acids, sulfonic acids and phosphorous acids into corresponding methyl esters, and did so with yields of up to 97% in 4 h at room temperature. Good substrate tolerance was observed, and benefited from the mild conditions and compatibility of the reaction with water.
L. Zeng, Y. Liu, J. Han, J. Chen, S. Liu and B. Xi, Org. Biomol. Chem., 2022, 20, 5230 DOI: 10.1039/D2OB00578F
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