Issue 30, 2022

Fluorogenic sydnonimine probes for orthogonal labeling

Abstract

A FRET-based fluorescence turn-on probe is designed, which employs a sydnonimine as the linker to match specific fluorophore and quencher pairs and releases the fluorescence after the “click-and-release” reaction. Furthermore, we realized selective fluorescence labeling by exploiting the mutual orthogonality between sydnonimine–DIBAC and tetrazine–1,3-Cp cycloaddition pairs.

Graphical abstract: Fluorogenic sydnonimine probes for orthogonal labeling

  • This article is part of the themed collection: New Talent

Supplementary files

Article information

Article type
Communication
Submitted
25 Jan 2022
Accepted
10 Mar 2022
First published
10 Mar 2022

Org. Biomol. Chem., 2022,20, 5953-5957

Fluorogenic sydnonimine probes for orthogonal labeling

W. Xu, Z. Shao, C. Tang, C. Zhang, Y. Chen and Y. Liang, Org. Biomol. Chem., 2022, 20, 5953 DOI: 10.1039/D2OB00159D

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