Issue 7, 2022
From the journal:

Organic & Biomolecular Chemistry

Regioselective synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds via transition metal-free C–C and C–N bond formation†

Danhua Ge, ORCID logo *a   Li-Wen Sun,a   Zi-Lun Yu,a   Xin-Long Luo,a   Pei Xu*b  and  Zhi-Liang Shen ORCID logo a  

* Corresponding authors

a Chemical Experiment Teaching Center, Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China
E-mail: gedanhua@njtech.edu.cn

b Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
E-mail: xupei@xzhmu.edu.cn

Abstract

Few methods are known for the synthesis of nitroindole derivatives. A simple and practical Cs2CO3-promoted method for the synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds has been developed. Two new C–C and C–N bonds were formed in a highly regioselective manner under transition metal-free conditions.

Graphical abstract: Regioselective synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds via transition metal-free C–C and C–N bond formation

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Article information

DOI
https://doi.org/10.1039/D1OB02443D
Article type
Paper
Submitted
17 Dec 2021
Accepted
19 Jan 2022
First published
19 Jan 2022

Org. Biomol. Chem., 2022,20, 1493-1499

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Regioselective synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds via transition metal-free C–C and C–N bond formation

D. Ge, L. Sun, Z. Yu, X. Luo, P. Xu and Z. Shen, Org. Biomol. Chem., 2022, 20, 1493 DOI: 10.1039/D1OB02443D

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