Issue 11, 2022

On the evolution of coenzyme biosynthesis


Covering: up to 2022

The report provides a broad approach to deciphering the evolution of coenzyme biosynthetic pathways. Here, these various pathways are analyzed with respect to the coenzymes required for this purpose. Coenzymes whose biosynthesis relies on a large number of coenzyme-mediated reactions probably appeared on the scene at a later stage of biological evolution, whereas the biosyntheses of pyridoxal phosphate (PLP) and nicotinamide (NAD+) require little additional coenzymatic support and are therefore most likely very ancient biosynthetic pathways.

Graphical abstract: On the evolution of coenzyme biosynthesis

Article information

Article type
Review Article
25 May 2022
First published
23 Sep 2022
This article is Open Access
Creative Commons BY license

Nat. Prod. Rep., 2022,39, 2175-2199

On the evolution of coenzyme biosynthesis

A. Kirschning, Nat. Prod. Rep., 2022, 39, 2175 DOI: 10.1039/D2NP00037G

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