Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases

Abstract

Covering: 1996–2022

Investigations over the last 2 decades have begun to reveal how fungal iterative highly-reducing polyketide synthases are programmed. Both in vitro and in vivo experiments have revealed the interplay of intrinsic and extrinsic selectivity of the component catalytic domains of these systems. Structural biology has begun to provide high resolution structures of hr-PKS that can be used as the basis for their engineering and reprogramming, but progress to-date remains rudimentary. However, significant opportunities exist for translating the current level of understanding into the ability to rationally re-engineer these highly efficient systems for the production of important biologically active compounds through biotechnology.

Graphical abstract: Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases

Article information

Article type
Review Article
Submitted
28 Jan 2022
First published
11 May 2022
This article is Open Access
Creative Commons BY license

Nat. Prod. Rep., 2022, Advance Article

Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases

R. J. Cox, Nat. Prod. Rep., 2022, Advance Article , DOI: 10.1039/D2NP00007E

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