Issue 45, 2022

Tailoring the electrocatalytic activity of porous carbon with heteroatom dopants for the quantification of acetaminophen in pharmaceuticals and biological samples

Abstract

Developing an efficient, metal-free, stable electrocatalyst for electrochemical applications is highly desirable and challenging. In the realm of catalysis, the heteroatom doping approach is a modulating strategy as well as a potential way of boosting the electrocatalytic activity of mesoporous carbon (MC). In this context, we propose an efficient nanocasting route followed by carbonization for synthesizing doped-MC. Due to the porous texture and synergic impact of dopants, nitrogen and phosphorous co-doped MC (NP-MC) were constructed using dopamine and phytic acid as precursors. Furthermore, NP-MC possesses a surface area of 970 m2 g−1 with a high amount of graphitic and pyridinic active sites. It was found that NP-MC exhibits higher electrochemical activity via the assay of acetaminophen (ACAP) by differential pulse voltammetry (DPV) and an amperometric procedure. On top of this, the prepared NP-MC material reached an ultra-low detection limit of 0.027 μM, with a wide linear range over a concentration from 3–4000 μM with appreciable sensitivity and selectivity. We demonstrated accurate detection with NP-MC for the real-time recognition of ACAP in human serum and pharmaceutical drugs as well as artificial sweat, saliva, and urine samples.

Graphical abstract: Tailoring the electrocatalytic activity of porous carbon with heteroatom dopants for the quantification of acetaminophen in pharmaceuticals and biological samples

Supplementary files

Article information

Article type
Paper
Submitted
13 Oct 2022
Accepted
25 Oct 2022
First published
25 Oct 2022

New J. Chem., 2022,46, 21875-21884

Tailoring the electrocatalytic activity of porous carbon with heteroatom dopants for the quantification of acetaminophen in pharmaceuticals and biological samples

N. Sivaraman, V. Duraisamy, S. Murugesan Senthil Kumar and R. Thangamuthu, New J. Chem., 2022, 46, 21875 DOI: 10.1039/D2NJ05030G

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