Synthesis and fungicidal activity of novel pyrroloindole scaffolds and their derivatives

Abstract

The key scaffold of a pyrroloindole ring is a very important structure, which is isolated from plants and fungi with a variety of medical and fungicidal activities. In this paper, a series of pyrroloindole analogues were synthesized from indole-3-acetonitrile and screened for their antifungal activities against plant pathogenic fungi. Compounds a2 and a15 exhibited potent antifungal activities with a minimum inhibitory concentration of 15.63 μg mL⁻¹ against 6 kinds of fungi, and can be used as novel antifungal agents for further development.