Rational design of ruddlesden–popper phase Mn2SnO4 for ultra-sensitive and highly selective detection of chloramphenicol in real-life samples

Abstract

A novel metal stannate (Mn₂SnO₄) nanocube electrocatalyst with an outstanding sensing capability and electrochemical properties is established by an ultrasonic-assisted technique. A variety of physicochemical and electrochemical methods were used to characterize the structural, surface morphological and electrochemical properties of Mn₂SnO₄. We then observed the analytical behaviour and applications of Mn₂SnO₄/GCE for the determination of chloramphenicol (CAP) by using various voltammetric techniques. The effects of the experimental conditions, such as the amount of modifier, sample concentration, scan rate and pH, on the peak current of CAP were studied. The proposed Mn₂SnO₄/GCE sensor shows a higher cathodic current in response to a wide dynamic linear range of 0.04–437.18 μM and superior electrocatalytic activity with an appreciably lower detection limit (0.0194 μM) and good sensitivity (0.1648μA μM⁻¹ cm⁻²), which were determined from differential pulse voltammetry (DPV). The practical applicability, such as repeatability, stability and reproducibility towards CAP, exhibits acceptable results. Consequently, the as-synthesized Mn₂SnO₄-modified sensor might be a potential candidate for the determination of CAP in milk powder and eye drop analyses and the results are noticeable.