Xanthosaponins A and B, two unusual steroidal saponins with an unprecedented 16,17-seco-cholestane skeleton from Solanum xanthocarpum and their cytotoxic activities

Abstract

Xanthosaponins A (1) and B (2), two unusual steroidal saponins with a new 16,17-seco-cholestane carbon skeleton were isolated from the fruits of Solanum xanthocarpum. The structures of all isolated compounds were determined using 1D and 2D NMR experiments and MS analyses. Xanthosaponin A (1) exhibited significant cytotoxic activity against MGC803, LN229, and SMMC7721 cells.