Issue 4, 2022

A ratiometric fluorescence platform composed of MnO2 nanosheets and nitrogen, chlorine co-doped carbon dots and its logic gate performance for glutathione determination

Abstract

Herein, a ratiometric fluorescence strategy based on MnO2 nanosheets and nitrogen, chlorine co-doped carbon dots (N, Cl-CDs) was constructed for selective determination of glutathione (GSH) and the absolute fluorescence quantum yield of N, Cl-CDs was 14.8%. The MnO2 nanosheets with oxidase-like activity could catalytically oxidize o-phenylenediamine (OPD) to generate the yellow fluorescent 2, 3-diaminophenazine (DAP). Moreover, the fluorescence of N, Cl-CDs was quenched by DAP through the inner filter effect (IFE). The fluorescence signal of DAP decreased at 565 nm, whereas that of N, Cl-CDs increased at 440 nm (at an excitation wavelength of 380 nm) because GSH decomposed the MnO2 nanosheets into Mn2+. The fluorescence intensity ratio of F440/F565 increased linearly in the range of 10–500 μM GSH and the limit of detection was 3 μM for GSH. The actual application of the established method in human serum samples was evaluated and verified by standard experiments, and the recoveries of spiked samples ranged from 96.6% to 108.1% with a relative standard deviation (RSD) less than 2.0% (n = 3). Moreover, a logic gate device was investigated by setting MnO2 nanosheets and GSH as two input signals and the emission of N, Cl-CDs and DAP as two outputs, implying that the sensing platform has potential application in the field of intelligent GSH detection systems.

Graphical abstract: A ratiometric fluorescence platform composed of MnO2 nanosheets and nitrogen, chlorine co-doped carbon dots and its logic gate performance for glutathione determination

Supplementary files

Article information

Article type
Paper
Submitted
04 Nov 2021
Accepted
03 Dec 2021
First published
06 Dec 2021

New J. Chem., 2022,46, 1972-1983

A ratiometric fluorescence platform composed of MnO2 nanosheets and nitrogen, chlorine co-doped carbon dots and its logic gate performance for glutathione determination

F. Bai, H. Wang, L. Lin and L. Zhao, New J. Chem., 2022, 46, 1972 DOI: 10.1039/D1NJ05210A

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