Issue 11, 2022

Importance of photophosphatidylserine and Tim-3 in photoimmunotherapy

Abstract

Natural killer (NK) cells help regulate autoimmune reactions, but overactivation causes harm. A Tim-3 receptor is an immune checkpoint that prevents overactivation. Its malfunction is related to autoimmune diseases and is mediated by phosphorylation of Tim-3 and other ligands. Photophosphatidylserine (phoPS) is a photoswitchable instrument that regulates NK cells through Tim-3. PS is bound to multiple receptors; therefore it can be utilised against cancer, infectious disorders, and autoimmune diseases, though more in vitro and in vivo research studies are needed.

Graphical abstract: Importance of photophosphatidylserine and Tim-3 in photoimmunotherapy

Article information

Article type
Opinion
Submitted
29 Jul 2022
Accepted
03 Oct 2022
First published
04 Oct 2022

RSC Med. Chem., 2022,13, 1274-1275

Importance of photophosphatidylserine and Tim-3 in photoimmunotherapy

A. Sharma, A. Kumar, S. Pandey and D. Kumar, RSC Med. Chem., 2022, 13, 1274 DOI: 10.1039/D2MD00189F

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