A sustainable nano drug delivery system for poorly soluble drug, glipizide: design, in vitro controlled release and kinetics

Abstract

The present work deals with the design of drug delivery systems based on 12-tungstophosphoric acid (TPA)-functionalized MCM-48 nanoparticles (TPA/nMCM-48), for poorly soluble drug GLP. Two DDSs, namely GLP loaded on TPA/nMCM-48 and capped by TPA, were designed and characterized by various techniques. An in vitro release study of GLP was carried out in simulated body fluid (pH-7.4, 37 °C) under stirring conditions followed by the evaluation of the release kinetics and mechanism. The release profiles of the designed DDSs were compared with the release profiles of a commercially available formulation (Glynase) and GLP/nMCM-48. The comparison study indicates that TPA acts better as a functionalizing agent rather than as a capping agent and when compared with the marketed formulation, GLP/TPA/nMCM-48 shows more controlled release of GLP with only 15% cytotoxicity.