Photoredox-catalyzed intermolecular dearomative trifluoromethylcarboxylation of indoles and heteroanalogues with CO2 and fluorinated radical precursors

Abstract

A photoredox-catalyzed intermolecular dearomative trifluoromethylcarboxylation of indoles and heteroanalogues with CO₂ and fluorinated radical precursors has been achieved. A range of substrates has been used in sequential conversion to generate polyfunctionalized benzoheterocycles under mild conditions in high yields with excellent regioselectivity and diastereoselectivity.