Issue 17, 2022

Metal/catalyst-free sequential C–N bond forming cascades at room temperature: environment-friendly one-pot synthesis of 5-aminoimidazoles from aryl glyoxals, anilines, and amidines

Abstract

An expeditious one-pot method for the synthesis of highly substituted 5-aminoimidazoles from glyoxals, anilines, and amidines was evaluated under metal/catalyst-free conditions operative at room temperature. The present protocol constitutes an environmentally friendly approach for the synthesis of highly substituted 5-aminoimidazoles, which are important building blocks of several bioactive and medicinal compounds. The readily and commercially available starting materials can be quickly assembled into imidazoles using this protocol and scaling up this process does not require chromatographic purification. Additionally, the reaction of 5-aminoimidazole with 2-bromobenzoyl chloride can provide a novel imidazo[5,1-b]quinazolin-9(4H)-one, thus showcasing the applicability of this protocol.

Graphical abstract: Metal/catalyst-free sequential C–N bond forming cascades at room temperature: environment-friendly one-pot synthesis of 5-aminoimidazoles from aryl glyoxals, anilines, and amidines

Supplementary files

Article information

Article type
Paper
Submitted
13 Apr 2022
Accepted
07 Jul 2022
First published
22 Jul 2022

Green Chem., 2022,24, 6501-6510

Metal/catalyst-free sequential C–N bond forming cascades at room temperature: environment-friendly one-pot synthesis of 5-aminoimidazoles from aryl glyoxals, anilines, and amidines

H. B. Jalani, A. Sivaraman, K. H. Min, H. Y. Lee, N. K. Oh, H. Kang, G. Keum, Y. Choi and K. Lee, Green Chem., 2022, 24, 6501 DOI: 10.1039/D2GC01407F

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