Directing the H2-driven selective regeneration of NADH via Sn-doped Pt/SiO2

Abstract

H₂-Driven NADH regeneration has long suffered from low selectivity when non-enzymatic, particularly heterogeneous catalysts, are used. In addition to the unselective nature of the catalysts, the typically unmeasured NAD⁺ conversion has inevitably hindered catalyst development. Here we report Sn-doped Pt/SiO₂ catalysts for the selective regeneration of NADH and show that doping Pt/SiO₂ with 10 at% Sn can deliver a selectivity of 90% (at full conversion) using H₂. We propose that this is a result of Sn disturbing the Pt ensemble, altering the mode of NAD⁺ adsorption and directing the reduction to the 1,4-position of the nicotinamide ring.