Cytotoxicity of fac-Mn(CO)3 complexes with a bidentate quinoline ligand towards triple negative breast cancer

Danira A. Habashy; Rabaa M. Khaled; Amr Y. Ahmed; Krzysztof Radacki; Salma K. Ahmed; Engy K. Tharwat; Hana Magdy; Alaa Zeinhom; Ahmed M. Mansour

doi:10.1039/D2DT01938H

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Cytotoxicity of fac-Mn(CO)₃ complexes with a bidentate quinoline ligand towards triple negative breast cancer†

Danira A. Habashy,

^a Rabaa M. Khaled,

^b Amr Y. Ahmed,

^a Krzysztof Radacki,

^c Salma K. Ahmed,

^d Engy K. Tharwat,

^d Hana Magdy,

^d Alaa Zeinhom

^d and Ahmed M. Mansour

*^b

Author affiliations

* Corresponding authors

^a Department of Pharmacology, Toxicology and Clinical Pharmacy, German University in Cairo, New Cairo, Egypt

^b Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt
E-mail: mansour@sci.cu.edu.eg, inorganic_am@yahoo.com

^c Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany

^d Department of Biotechnology, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt

Abstract

The cytotoxicity of two tricarbonyl Mn(I) complexes of the general formula fac-[MnBr(CO)₃L] (L = quinoline-2-carboxaldehyde (A) and 8-amino quinoline (B)) towards triple negative breast cancer (MDA-MB-231) was reported. Complexes A and B released CO when exposed to 468 nm light. Compound B has a dose-dependent cytotoxicity, with half maximal inhibitory concentration values of 19.62 μM and 11.43 μM before and after illumination, respectively. Co-treatment of MDA-MB-231 with paclitaxel (30 nM) and complex B (10 μM) resulted in a 50% reduction in cell viability.

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Article information

DOI: https://doi.org/10.1039/D2DT01938H
Article type: Communication
Submitted: 19 Jun 2022
Accepted: 01 Sep 2022
First published: 15 Sep 2022

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Dalton Trans., 2022,51, 14041-14048

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Cytotoxicity of fac-Mn(CO)₃ complexes with a bidentate quinoline ligand towards triple negative breast cancer

D. A. Habashy, R. M. Khaled, A. Y. Ahmed, K. Radacki, S. K. Ahmed, E. K. Tharwat, H. Magdy, A. Zeinhom and A. M. Mansour, Dalton Trans., 2022, 51, 14041 DOI: 10.1039/D2DT01938H

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