Issue 18, 2022

Might Cu(ii) binding, DNA cleavage and radical production by YadA fragments be involved in the promotion of F. nucleatum related cancers?

Abstract

In many cases, human microbiota are associated with cancer progression. It was concluded that Fusobacterium nucleatum increases neoplastic changes. This bacterium is naturally present in human dental plaque. However, if it is present in the colon, it becomes a precursor of cancer. Antibiotic treatment of mice infected with F. nucleatum slowed tumor growth, which agrees with the fundamental role of bacteria in tumorigenesis. Remarkably, recent studies indicate that transition metal complexes with fragments of outer membrane proteins are able to promote reactive oxygen species (ROS) formation and are responsible for oxidative stress, which consequently leads to cell damage. Therefore, in this paper, the formation of copper(II) complexes with fragments of adhesin YadA from F. nucleatum is characterized. Moreover, the ability of the complexes to produce ROS has been shown. Importantly, free ligands are efficient DNA-cleaving agents.

Graphical abstract: Might Cu(ii) binding, DNA cleavage and radical production by YadA fragments be involved in the promotion of F. nucleatum related cancers?

Article information

Article type
Paper
Submitted
02 Feb 2022
Accepted
14 Mar 2022
First published
17 Mar 2022

Dalton Trans., 2022,51, 7040-7052

Might Cu(II) binding, DNA cleavage and radical production by YadA fragments be involved in the promotion of F. nucleatum related cancers?

K. Stokowa-Sołtys, K. Kierpiec and R. Wieczorek, Dalton Trans., 2022, 51, 7040 DOI: 10.1039/D2DT00328G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements