Highly stable spherical shaped and blue photoluminescent cyclodextrin-coated tellurium nanocomposites prepared by in situ generated solvated electrons: a rapid green method and mechanistic and anticancer studies

Abstract

Highly stable blue photoluminescent tellurium nanocomposites (Te NCs) coated with a molecular assembly of α-cyclodextrin (α-CD) have been prepared by using in situ generated solvated electrons (e_sol⁻) in the reaction media. The methodology used is rapid and green as the preparation of colloids was over in a matter of a few seconds and no hazardous agents (reducing or stabilizing) were used. Furthermore, fine control over the size of Te NCs has been demonstrated by simply varying the absorbed irradiation dose. As a matter of fact, the anisotropic property exhibited by tellurium makes it difficult to control the phase and morphology of its nanomaterials. However, unlike the majority of the previous reports, Te NCs formed by the current approach were amorphous and spherical shaped. Another interesting aspect of this work is the cyan-blue photoluminescence (PL) exhibited by the NCs. Systematic photophysical investigations indicated bandgap radiative decay as the origin of photoluminescence. A compositional analysis indicated the presence of Te(0) along with tellurium oxides (TeO_x). TGA studies revealed the formation of a dense coating (∼55%) of α-CD molecules on the NCs. Pulse radiolysis–based studies evidenced the formation of Te-based transients by the solvated electron-induced reaction. Importantly, no interference of α-CD was observed in the kinetics of the transient species. Remarkable concentration-dependent killing was observed only in the case of cancerous cells, while no such trend was seen in normal healthy cells. This is a significant observation that can be utilized to achieve differential toxicity of Te nanomaterials in tumor versus normal cells.